Search results for "51cr edta"

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Comparison of cystatin C and creatinine-based glomerular filtration rate formulas with 51Cr-EDTA clearance in patients with cirrhosis

2011

Renal function is an important predictor of survival in cirrhosis and liver transplantation. GFR estimates using serum cystatin C (CysC) are proposed as better predictors of renal function than ones on the basis of serum creatinine (Cr). Our aims were: (1) evaluate correlations between serum CysC and different methods of creatinine measurements; (2) compare CysC and Cr GFR formulas with (51)Cr-EDTA; and (3) evaluate liver-related parameters potentially influencing GFR.254 blood samples in 65 patients with cirrhosis correlating CysC with four Cr methods were used; another 74 patients comparing (51)Cr-EDTA GFR to Modification of Diet in Renal Disease and Larsson and Hoek formulas for CysC wer…

AdultLiver CirrhosisMalemedicine.medical_specialtyCirrhosisBilirubinEpidemiologymedicine.medical_treatmentUrologyRenal functionLiver transplantationurologic and male genital diseasesCritical Care and Intensive Care MedicineAdult; Aged; Aged 80 and over; Bilirubin; Creatinine; Cystatin C; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Multivariate Analysis; Chromium Radioisotopes; Edetic Acid; Glomerular Filtration Rate; Nephrology; Transplantation; Epidemiology; Critical Care and Intensive Care Medicinechemistry.chemical_compoundBayesian multivariate linear regressionInternal medicine80 and overMedicineHumansCystatin CEdetic AcidAgedAged 80 and overCreatinineTransplantationbiologybusiness.industrycirrhosisBilirubinOriginal Articles51cr edta clearanceMiddle Agedmedicine.diseaseChromium RadioisotopesEndocrinologyCystatin CchemistryNephrologyCreatinineMultivariate Analysisbiology.proteinFemalebusinessGlomerular Filtration Rate
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Preclinical Effect of Absorption Modifying Excipients on Rat Intestinal Transport of Model Compounds and the Mucosal Barrier Marker 51Cr-EDTA

2017

There is a renewed interest from the pharmaceutical field to develop oral formulations of compounds, such as peptides, oligonucleotides, and polar drugs. However, these often suffer from insufficient absorption across the intestinal mucosal barrier. One approach to circumvent this problem is the use of absorption modifying excipient(s) (AME). This study determined the absorption enhancing effect of four AMEs (sodium dodecyl sulfate, caprate, chitosan, N-acetylcysteine) on five model compounds in a rat jejunal perfusion model. The aim was to correlate the model compound absorption to the blood-to-lumen clearance of the mucosal marker for barrier integrity, 51Cr-EDTA. Sodium dodecyl sulfate a…

KetoprofenFysiologiPhysiologyabsorption modifiersPharmaceutical ScienceExcipient51cr edtaPharmacology and Toxicology02 engineering and technologyAbsorption (skin)030226 pharmacology & pharmacyChitosan03 medical and health scienceschemistry.chemical_compound0302 clinical medicineintestinal perfusionDrug DiscoverymedicineIntestinal transportSodium dodecyl sulfatebioequivalenceChromatographypermeation enhancersPermeationFarmakologi och toxikologi021001 nanoscience & nanotechnologypharmaceutical developmentchemistryMolecular Medicine0210 nano-technologymedicine.drugMolecular Pharmaceutics
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